CWI1-2 HCL

SKU: orb1745214

Description

CWI1-2 HCL is a small molecule inhibitor of IGF2BP2 that disrupts its interaction with m6A-modified transcripts. This action promotes apoptosis and differentiation in leukemia cells, demonstrating therapeutic potential in preclinical research models.

Research Area

Cell Biology

Key Properties

• CAS Number: 2408590-37-2
• MW: 556.23
• Purity: 99.18% (May vary between batches)
• Formula: C₂₂H₁₈Cl₄N₆O₃
• SMILES: OC1=CC=C(Cl)C=C1/C=N\N/C(N/N=C/C2=CC(Cl)=CC=C2O)=N/N=C/C3=CC(Cl)=CC=C3O.Cl
• Target: Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (1.8 mM);DMSO:145 mg/mL (260.68 mM)

Bioactivity

• In Vivo:
  CWI1-2 hydrochloride (5 mg/kg, i.v., once daily, 7-10 days) significantly delays leukemia onset and prolongs survival in BMT recipient B6.SJL (CD45.1) mice, without significantly affecting body weight.
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• In Vitro:
  CWI1-2 (0-1 μM, 24 h) hydrochloride demonstrates significant anti-leukemia efficacy.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, CWI1-2 HCL, CWI12HCL

Compound Identifiers

PubChem CID

168265662