CVT-10216

SKU: orb1308421

Description

CVT-10216

Research Area

Metabolism Research

Key Properties

• CAS Number: 1005334-57-5
• MW: 465.48
• Purity: 99.16%
• Formula: C₂₄H₁₉NO₇S
• SMILES: CS(=O)(=O)Nc1ccc(cc1)-c1coc2cc(OCc3cccc(c3)C(O)=O)ccc2c1=O
• Target: Dehydrogenase
• Solubility: DMF:25 mg/mL (53.71 mM);DMSO:20 mg/mL (42.97 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.3 mM)

Bioactivity

• Target IC50:
  ALDH2:29 nM
• In Vivo:
  CVT-10216 is a highly selective, reversible inhibitor of ALDH-2 that reduces excessive alcohol drinking. Anxiety plays a role in alcoholism. As reflected in social interaction behavior in four unrelated rodent models: endogenous anxiety-like behavior in na ve Fawn-Hooded rats, repeated alcohol-withdrawal-induced anxiety, restraint stress-induced anxiety and drug-induced anxiety. CVT-10216 counteracted anxiety in all models except that produced by the 5-HT(2C) agonist, mCPP. CVT-10216 exhibited both acute and prophylactic inhibitions of repeated alcohol-withdrawal-induced anxiety. Importantly, anxiogenic behavior induced by the benzodiazepine receptor inverse agonist, DMCM, was counteracted dose-dependently by CVT-10216.CVT-10216 (intraperitoneal injection; 3.75 or 15 mg/kg) are determined 5 h into the third withdrawal, it has the anxiolytic effect of 15 mg/kg CVT-10216 in this model. However it has no significant effects on locomotor activity. CVT-10216 (intraperitoneal injection; 3.75, 7.5, or 15 mg/kg) shows a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

social, CVT-10216, CVT10216, CVT 10216, ALDH2, ALDH-2, Aldehyde Dehydrogenase (ALDH), ALDH, alcohol-preferring, anxiolytic, inhibit, interaction, Inhibitor

Compound Identifiers

PubChem CID

23661666