Cutamesine dihydrochloride

SKU: orb1304015

Description

Cutamesine dihydrochloride

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 165377-44-6
• MW: 441.43
• Purity: 99.96%
• Formula: C₂₃H₃₂N₂O₂·2HCl
• SMILES: Cl.Cl.COc1ccc(CCN2CCN(CCCc3ccccc3)CC2)cc1OC
• Target: Sigma receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.27 mM);H2O:100 mg/mL (226.54 mM);DMSO:10 mg/mL (22.65 mM)

Bioactivity

• Target IC50:
  σ1 receptor:17.4 nM
• In Vivo:
  SA4503 extends the survival time in the SOD1 g93A mice.
• In Vitro:
  The sigma receptor is implicated in various central nervous system diseases. SA4503, a potent σ1 receptor agonist, exhibits a 103-fold higher affinity for σ1 (IC50=17.4 nM) than σ2 (IC50=1,784 nM) in guinea pig brain membranes and is 14-fold selective for σ1 (Ki=4.6 nM) over σ2 (Ki=63.1 nM) in guinea pig brain homogenates. SA4503 protects motor neuron NSC34 cells against superoxide dismutase 1 and serum-free neurotoxicity, upregulating phosphorylation levels of Akt and extracellular signal-regulated kinase (ERK) 1/2, while reducing MAPK/ERK pathway activation and down-regulating the ionotropic glutamate receptor, GluR1.
• Cell Research:
  The NSC34 cells are seeded at a density of 7000 cells per well into 96-well plates with D-MEM and transfected using Lipofectamine 2000 mixed with 2 μg /mL of plasmid vector in D-MEM for 6 h. After 6 h, the cell-culture medium is replaced with fresh D-MEM and culture and allowed to proceed for a further 42 h. The cells are then transferred to serum-free D-MEM and immediately treated with SA4503 at a final concentration of 1, 3, or 10 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, AGY 94806, AGY 94806 Dihydrochloride, AGY94806, AGY-94806, AGY94806 dihydrochloride, AGY94806 Dihydrochloride, AGY-94806 Dihydrochloride, Cutamesine, Cutamesine Dihydrochloride, Cutamesine dihydrochloride, SA 4503, SA 4503 Dihydrochloride, SA4503, SA-4503, SA4503 (dihydrochloride), SA4503 Dihydrochloride, SA4503 dihydrochloride, SA-4503 Dihydrochloride, Sigmareceptor, Sigma Receptor, Sigma receptor, σ1

Compound Identifiers

PubChem CID

9954941