Curculigoside

SKU: orb1221723

Description

Curculigoside can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disorders. Curculigoside can promote calcium deposition and increase the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character. Curculigoside possesses potent antioxidant properties against oxidative stress insults. can protect endothelial cells against oxidative injury induced by H2O2, suggesting that this compound may constitute a promising intervention against cardiovascular disorders.

Key Properties

• CAS Number: 85643-19-2
• MW: 466.43
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₆O₁₁
• SMILES: COC1=C(C(=CC=C1)OC)C(=O)OCC2=C(C=CC(=C2)O)OC3C(C(C(C(O3)CO)O)O)O
• Target: Antioxidant
• Solubility: In Vitro: DMSO : 100 mg/mL (214.39 mM)

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: MH7A cells. Concentration: 1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml; 16 μg/ml; 32 μg/ml; 64 μg/ml. Incubation time: 72 hours. Result: Had inhibitory effect on MH7A cells. Western blot analysis. Cell line: MH7A cells. Concentration: 4 μg/ml; 64 μg/ml. Incubation time: 24 hours. Result: Downregulated JAK1, JAK3 and STAT3 protein expression.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Curculigoside A | Curculigoside-A

Quick Database Links

Gene Symbol

Antioxidant