CUR61414

SKU: orb1707418

Description

CUR61414 is a potent and cell-permeable smoothened (SMO) antagonist with a Ki of 44 nM, inhibiting the Hedgehog signaling pathway with an IC50 of 100-200 nM. This small molecule inhibitor is a valuable tool for probing Hh pathway biology in both cellular assays and in vivo disease models, including cancer research.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 334998-36-6
• MW: 550.71
• Purity: >98%
• Formula: C₃₁H₄₂N₄O₅
• SMILES: COc1cccc(CN([C@H]2C[C@H](N(Cc3ccc4OCOc4c3)C2)C(=O)N2CCNCC2)C(=O)CC(C)(C)C)c1
• Target: GPCR
• Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).

Bioactivity

• In Vivo:
  CUR61414 regresses these lesions in the mice exposed to UV light irradiation and produces many microscopic BCC-like basaloid lesions throughout their skin.
• In Vitro:
  CUR61414 arrests the proliferation of basal cells within the BCC-like lesions and induces cell apoptosis and complete regression of the lesions, without affecting neighboring non-tumor cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Smoothened, Hedgehog inhibitor, Hedgehog, CUR 61414, CUR61414, CUR-61414

Compound Identifiers

PubChem CID

10392802