Cuminaldehyde

SKU: orb1299816

Description

Cuminaldehyde is a naturally occurring aromatic aldehyde that inhibits alpha-synuclein fibrillation and cytotoxicity. It exhibits anticancer properties in vitro and is a key fragrant component of essential oils, making it relevant for neurodegenerative and oncology research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 122-03-2
• MW: 148.2
• Purity: 98.00% (May vary between batches)
• Formula: C₁₀H₁₂O
• SMILES: CC(C)c1ccc(C=O)cc1
• Target: Endogenous Metabolite
• Solubility: DMSO:25 mg/mL (168.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (13.5 mM)

Bioactivity

• In Vivo:
  In vivo, cuminaldehyde diminished the tumor burden ,cuminaldehyde could be a drug for chemopreventive or anticancer therapy
• In Vitro:
  Cuminaldehyde suppressed growth and induced apoptosis, as proved by depletion of the mitochondrial membrane potential, activation of both caspase-3 and -9, and morphological features of apoptosis.
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• Cell Research:
  Incubated the cells in the culture plate with 96 wells at the concentration of ten thousand cells per well. After being incubated for 24 h, we treated the cells with cuminaldehyde at the concentration of 10, 20, 40, 80, or 160 μM for 12, 24, or 48 h. Determined cell viability using the Cell Proliferation Kit II (XTT) according to the supplier's instructions. The value of absorbance was evaluated by a spectrophotometer (Tecan infinite M200, Tecan, M nnedorf, Switzerland) using 492 nm wavelength with a reference of 650 nm wavelength.
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• Animal Research:
  Human colorectal COLO 205 cells (5 × 10^6 cells in 200 μL of culture medium) were subcutaneously injected into the mice's flanks. Treatment was started when the tumors reached about 75 mm^3. Thirty-two mice were divided randomly into four groups (eight mice/group). Cuminaldehyde-treated mice received intratumoral injection of 5, 10, or 20 mg/kg/day of cuminaldehyde in a 200 μL volume (the solutions were prepared from stock solution of cuminaldehyde in dimethyl sulfoxide and diluted into appropriate concentrations in PBS) daily. The mice in the control group were treated with an equal volume of vehicle. After transplantation, body weight as well as tumor size were monitored at weekly intervals. Tumor size was measured using calipers, and tumor volume was calculated using the hemiellipsoid model formula
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cuminal, Cuminaldehyde, Cuminic aldehyde, inhibit, Endogenous Metabolite, EndogenousMetabolite, Inhibitor

Compound Identifiers

PubChem CID

326