Cucurbitacin IIA

SKU: orb1303390

Description

Cucurbitacin IIA is a bioactive compound that induces apoptosis and enhances autophagy, contributing to its anti-inflammatory effects. It also acts as an anti-cancer agent by disrupting the actin cytoskeleton and inhibiting the JAK2/STAT3/survivin pathway, leading to PARP-mediated cell death. Its mechanisms are studied in vitro for oncology and inflammation-related disease research.

Research Area

Cell Biology

Key Properties

• CAS Number: 58546-34-2
• MW: 562.73
• Purity: 99.87% (May vary between batches)
• Formula: C₃₂H₅₀O₈
• SMILES: [H][C@@]1([C@H](O)C[C@@]2(C)[C@]3([H])CC=C4[C@@]([H])(C[C@H](O)[C@@H](O)C4(C)C)[C@]3(C)C(=O)C[C@]12C)[C@@](C)(O)C(=O)CCC(C)(C)OC(C)=O
• Target: Apoptosis,Survivin
• Solubility: DMSO:91 mg/mL (161.71 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.55 mM);Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Survivin, Inhibitor, inhibit, Hemslecin A, Curcurbitacin IIA, Cucurbitacin IIA, Dihydrocucurbitacin Q1, Apoptosis

Compound Identifiers

PubChem CID

181183