Cucurbitacin D

SKU: orb1684984

Description

Cucurbitacin D is a bioactive triterpenoid from Ecballium elaterium with demonstrated anticancer properties. It inhibits proliferation and metabolic pathways in various cancer cell lines, including prostate, liver, and leukemia models, by targeting key signaling cascades such as JAK/STAT3 and PI3K/Akt. This compound also acts as a novel inflammasome activator in macrophages, making it a valuable tool for oncology and immunology research.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 3877-86-9
• MW: 516.67
• Purity: 97.69% (May vary between batches)
• Formula: C₃₀H₄₄O₇
• SMILES: CC(C)(O)\C=C\C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C[C@H](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C
• Target: Apoptosis
• Solubility: DMSO:80 mg/mL (154.84 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (6.39 mM)

Bioactivity

• In Vitro:
  Immunomodulating activities of Cucurbitacin D were investigated in macrophages. Cucurbitacin D could increase LPS-induced interleukin (IL)-1β production in culture supernatant of THP-1 cells, peritoneal exudate cells (PECs), bone marrow derived macrophages (BMDMs), and RAW264 cells. At the transcriptional level, Cucurbitacin D enhanced LPS-induced IL-1β mRNA expression through activation of ERK1/2 mitogen-activated protein kinases (MAPKs). At the posttranscriptional level, the activation of caspase-1 induced by Cucurbitacin D has also been demonstrated following treatment with a caspase-1 inhibitor and siRNA. Importantly, Cucurbitacin D has further been shown to induce inflammasome activation independent of ERK1/2 activation. Western blotting showed interaction of NOD-like receptor family, pyrin domain containing 3 (NALP3) and apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC), suggesting activation of the inflammasome and a possible reason for activation of caspase-1
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Cucurbitacin D, IL Receptor, JNK, STAT

Compound Identifiers

PubChem CID

5281318