CU-CPT-9a

SKU: orb1299926

Description

CU-CPT-9a is a highly potent and selective TLR8 inhibitor with an IC50 of 0.5 nM. It effectively blocks TLR8-driven inflammatory responses in diverse cellular models, including human primary cells. This tool compound is valuable for studying TLR8 biology in autoimmune, inflammatory, and infectious disease research contexts, both in vitro and in vivo.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2165340-32-7
• MW: 265.31
• Purity: 99.01% (May vary between batches)
• Formula: C₁₇H₁₅NO₂
• SMILES: COc1ccc2c(ccnc2c1)-c1ccc(O)c(C)c1
• Target: TLR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.08 mM);DMSO:150 mg/mL (565.38 mM)

Bioactivity

• Target IC50:
  TLR8:0.5 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CU CPT 9a, CUCPT9a, CU-CPT-9a, inhibit, Inhibitor, Toll-like Receptor (TLR), TLR, TLR8

Compound Identifiers

PubChem CID

135567383