CU CPT 4a

SKU: orb1218967

Description

CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells.

Key Properties

• CAS Number: 1279713-77-7
• MW: 377.82
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₃ClFNO₃S
• SMILES: O=C(O)[C@@H](CC1=CC=CC=C1)NC(C2=C(Cl)C3=CC=C(F)C=C3S2)=O
• Target: TLR
• Solubility: DMSO:<37.78mg/ml

Bioactivity

• In Vitro:
  CU-CPT 4a shows dose-dependent inhibitory effects blocking Poly (I: C)-induced TLR3 activation with an IC50 of 3.44 μM. CU-CPT 4a competes with dsRNA for binding to TLR3 with a Ki of 2.96 μM.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TLR