CTx0294885

SKU: orb1226275

Description

CTX-0294885 is a a novel bisanilino pyrimidine; exhibits inhibitory activity against a broad range of kinases in vitro, and further developed it into a Sepharose-supported kinase capture reagent.(In Vitro):CTX-0294885 is a kinase capture tool in large-scale kinome profiling experiments, with 185 kinases identified as total protein, and 179 identified from TiO2 enrichment for phosphopeptides in MDA-MB-231 cells (by quantitative MS).CTX-0294885 captures all members of the AKT family that is not identified from previous studies using other kinase capture reagents.

Key Properties

• CAS Number: 1439934-41-4
• MW: 437.93
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₄ClN₇O
• SMILES: O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCNCC4)C=C3)=NC=C2Cl
• Target: Kinase capture reagent
• Solubility: DMSO: 10 mM

Bioactivity

• In Vitro:
  CTX-0294885 is a kinase capture tool in large-scale kinome profiling experiments, with 185 kinases identified as total protein, and 179 identified from TiO2 enrichment for phosphopeptides in MDA-MB-231 cells (by quantitative MS). CTX-0294885 captures all members of the AKT family that is not identified from previous studies using other kinase capture reagents.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CTX0294885 | CTX 0294885 | CTX-0294885

Quick Database Links

Gene Symbol

Kinase capture reagent