CTX-439

SKU: orb3210999

Description

CTX-439 is an orally active ATP-competitive small molecule inhibitor of CDK12 and CDK13, with an IC50 of 3.1 nM and a Kd of 0.38 nM for CDK12, and an IC50 of 9.2 nM for CDK13. CTX-439 can induce DNA damage and apoptosis in tumor cells and is applicable for research in breast and ovarian cancer.

Key Properties

• CAS Number: 2377487-13-1
• MW: 671.69
• Formula: C₃₀H₃₂F₃N₉O₄S
• SMILES: C(F)(F)(F)C=1C(=NC(N[C@@H]2CC[C@@H](N(C(CCC)=O)C=3C=NC(=CN3)C=4C=NC(OC)=NC4)CC2)=NC1)C=5C=C(S(C)(=O)=O)C=NC5
• Target: CDK,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK,Apoptosis