CT-179

SKU: orb1739473

Description

CT-179

Research Area

Neuroscience

Key Properties

• CAS Number: 1996636-69-1
• MW: 397.3
• Purity: 98.67% (May vary between batches)
• Formula: C₁₇H₂₂Cl₂N₆O
• SMILES: CN(C)CCCNc1cc(C)nc(NC(=O)Nc2ccc(Cl)c(Cl)c2)n1
• Target: OLIG2

Bioactivity

• In Vivo:
  Methods: CT-179 (50 mg/kg, ip, twice weekly for 2 weeks) was combined with RT (8 Gy, 2 Gy fractions) to treat immunocompromised NOD rag γ (NRG) mice implanted with orthotopic Daoy-luci (SHH-MB) to investigate whether it exhibits similar antitumor activity against human MB in vivo. Results: Animals treated with CT-179 + RT had significantly slower progression and significantly delayed tumor growth in the brain and spinal cord; CT-179 combined with RT significantly prolonged EFS.
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• In Vitro:
  Methods: Daoy, UW228, and Med-813 MB cells were treated with CT-179 (0.01-10 μM, 7 days), and cell viability was determined by MTT assay. Results: CT-179 showed activity in all three cell lines, with IC50 values ​​of 143.6 nM, 285.4 nM, and 985.2 nM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IMG7289, IMG 7289, Bomedemstat ditosylate, CT179, CT-179, CT 179

Compound Identifiers

PubChem CID

122520266