CT-133

SKU: orb3175043

Description

CT-133 is a selective and potent antagonist of the CRTH2 Receptor, with a Ki value of 2.2 nM, and exhibits a Ki greater than 3800 nM for the DP1 receptor. It inhibits PGD2-induced neutrophil migration and significantly reduces lung inflammation and improves lung function impairment in a mouse model of acute lung injury (ALI) induced by cigarette smoke. Additionally, CT-133 effectively suppresses the overexpression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and the chemokine (KC) while reversing the suppression of the anti-inflammatory factor IL-10. CT-133 is useful for ALI research.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2417155-47-4
• MW: 441.45
• Formula: C₂₀H₂₁FN₃NaO₄S
• SMILES: C(C(O)=O)C1=C2N(C=3C1=CC=CN3)C[C@H](N(S(=O)(=O)C4=CC=C(F)C=C4)C)CC2.[Na]
• Target: Prostaglandin Receptor,TNF,Interleukin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Prostaglandin Receptor,TNF,Interleukin