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CSN5-IN-3

SKU: orb3210706

Description

CSN5-IN-3 (Compound 30) is a CSN5 inhibitor with an IC50 value of 0.58 μM. It inhibits the enzymatic activity of CSN5, leading to increased accumulation of NEDD8-Cul1 and promoting the degradation of PD-L1. CSN5-IN-3 downregulates Bcl-2, while upregulating P53 and Cleaved caspase-3, exhibiting anticancer properties against triple-negative breast cancer.

Images & Validation

Key Properties

TargetPD-1/PD-L1,MDM-2/p53,Caspase,Bcl-2 Family

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information