CSF1R-IN-3

SKU: orb1685973

Description

CSF1R-IN-3 is a potent and orally bioavailable CSF-1R inhibitor (IC50 = 2.1 nM). It demonstrates anti-tumor activity in colorectal cancer models by suppressing macrophage migration and promoting M2-to-M1 repolarization, which enhances anti-tumor immunity in both cellular and animal studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2760584-90-3
• MW: 574.67
• Purity: 98.40% (May vary between batches)
• Formula: C₃₀H₃₈N₈O₄
• SMILES: CN1CCN(CC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4cc(NC(=O)Nc5cc(on5)C(C)(C)C)ccc34)c2C)CC1
• Target: CSF-1R,c-Fms
• Solubility: DMSO:56.2 mg/mL (97.8 mM)

Bioactivity

• Target IC50:
  CSF1R:2.1 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CSF1R, CSF-1R, cFms, c-Fms

Compound Identifiers

PubChem CID

162719835