CSF1R-IN-26

SKU: orb3028900

Description

CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3077238-23-1
• MW: 415.87
• Formula: C₂₀H₂₂ClN₅O₃
• SMILES: O(C=1C=2C(NC1)=NC=C(Cl)C2)C3=C(C)N=C(NC(N[C@H]4[C@H](O)CCCC4)=O)C=C3
• Target: c-Fms,STAT,Akt,ERK,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

c-Fms,STAT,Akt,ERK,Apoptosis