CSF1R-IN-22

SKU: orb2566581

Description

CSF1R-IN-22 is a potent and selective CSF-1R inhibitor that reprograms M2 macrophages to an M1 phenotype, enhancing CXCL9 secretion and CD8+ T cell infiltration in the tumor microenvironment. It demonstrates synergistic anti-tumor activity with anti-PD-1 therapy in preclinical models, reducing immunosuppressive cell populations like Tregs and MDSCs.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2760585-35-9
• MW: 392.41
• Formula: C₂₀H₂₀N₆O₃
• SMILES: C(=C\1/C=2C(=CC(NC(NC=3C=C(C(C)(C)C)ON3)=O)=CC2)NC1=O)\C4=CN=CN4
• Target: c-Fms,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162719825