CS47

SKU: orb3173158

Description

CS47 is a reversible inhibitor of thioredoxin reductase 1 (TrxR1). It activates stress-responsive glutathione (GSH) and iron regulatory pathways, leading to GSH depletion. This results in reactive oxygen species (ROS) accumulation, promoting HO-1 overexpression and causing intracellular iron overload, which ultimately induces ferroptosis in lung cancer not dependent on the KRAS gene. CS47 exhibits anticancer activity with low cytotoxicity to normal lung fibroblasts.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 1372792-51-2
• MW: 595.21
• Formula: C₂₁H₁₆AuCl₂N₂P
• SMILES: ClC=1N=C[N-]([Au+][P](C=2C=CC=CC2)(C=3C=CC=CC3)C=4C=CC=CC4)C1Cl
• Target: ROS,Ferroptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS,Ferroptosis