CRT-0105446

SKU: orb1703577

Description

CRT-0105446 is a potent and selective LIM kinase (LIMK) inhibitor. It functions by inhibiting cofilin phosphorylation, which promotes actin depolymerization, and by enhancing α-tubulin acetylation to modulate microtubule stability. This small molecule is a valuable research tool for studying cytoskeleton dynamics in cancer cell migration and neuronal development in vitro.

Research Area

Cell Biology

Key Properties

• CAS Number: 1661846-05-4
• MW: 421.44
• Formula: C₂₀H₁₈F₃N₃O₂S
• SMILES: C(F)(F)(F)C1=C(C=2C(=CC=NC2)C=3SC(NC(C(C)C)=O)=NC3)C=CC(OC)=C1
• Target: LIM Kinase,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

117918919