Crolibulin

SKU: orb1308426

Description

Crolibulin (EPC2407) is a small molecule agent that disrupts tubulin polymerization. It has demonstrated antitumor activity in preclinical studies, inhibiting cancer cell proliferation in vitro and showing efficacy in vivo models of solid tumors.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1000852-17-4
• MW: 417.26
• Purity: 98.19% (May vary between batches)
• Formula: C₁₈H₁₇BrN₄O₃
• SMILES: COc1cc(cc(Br)c1OC)[C@H]1C(C#N)=C(N)Oc2c(N)c(N)ccc12
• Target: Microtubule Associated,Apoptosis
• Solubility: DMSO:120 mg/mL (287.59 mM)

Bioactivity

• Target IC50:
  Tubulin polymerization:0.52 μM
• In Vitro:
  Crolibulin demonstrates notable cytotoxic effects on HT-29 cells, achieving an IC50 value of 0.52 μM. It is effective against a range of experimental tumors and significantly inhibits mitosis during the G2/M phase.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EPC2407, EPC-2407, EPC 2407, Inhibitor, inhibit, Microtubule Associated, MicrotubuleAssociated, Microtubule/Tubulin, cancer, antineoplastic, antiproliferative, anaplastic, arrest, Apoptosis, cycle, Crolibulin, cell, colchicine-binding, thyroid, site, tubulin polymerization

Compound Identifiers

PubChem CID

23649181