Crizotinib hydrochloride

SKU: orb1298966

Description

Crizotinib hydrochloride (PF-02341066 hydrochloride) is a potent small molecule inhibitor targeting anaplastic lymphoma kinase (ALK) and c-Met with IC50 values of 20 nM and 8 nM, respectively. It is widely used in preclinical research for investigating non-small cell lung cancer and other malignancies, demonstrating efficacy in both cellular assays and animal models.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1415560-69-8
• MW: 486.8
• Purity: 98.73% (May vary between batches)
• Formula: C₂₁H₂₃Cl₃FN₅O
• SMILES: Cl.C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
• Target: ALK,Autophagy,ROS,c-Met/HGFR,ROS Kinase
• Solubility: DMSO:10 mg/mL (20.54 mM);H2O:50 mg/mL (102.71 mM)

Bioactivity

• Target IC50:
  ALK:20 nM |c-Met:8 nM
• In Vitro:
  Crizotinib hydrochloride(PF-2341066)potently inhibited NPM-ALK phosphorylation in Karpas299 or SU-DHL-1 ALCL cells (mean IC(50) value, 24 nmol/L). In biochemical and cellular screens, PF-2341066 was shown to be selective for c-Met and ALK at pharmacologically relevant concentrations across a panel of >120 diverse kinases. PF-2341066 potently inhibited cell proliferation, which was associated with G(1)-S-phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC(50) values, approximately 30 nmol/L) but not ALK-negative lymphoma cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PF02341066, PF-02341066 hydrochloride, PF-02341066, PF02341066 Hydrochloride, PF-02341066 Hydrochloride, PF 02341066, PF 02341066 Hydrochloride, ROS, ROSKinase, ROS Kinase, inhibit, Inhibitor, HGFR, Crizotinib, Crizotinib Hydrochloride, Crizotinib hydrochloride, c-Met, cMet/HGFR, cMet, c-Met/HGFR, CD246, Cluster of differentiation 246, Anaplastic lymphoma kinase, Anaplastic lymphoma kinase (ALK), Autophagy, ALK tyrosine kinase receptor, ALK

Compound Identifiers

PubChem CID

71576688