CRA-026440 hydrochloride

SKU: orb1709983

Description

CRA-026440 hydrochloride

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 847459-98-7
• MW: 456.92
• Purity: 99.78%
• Formula: C₂₃H₂₅ClN₄O₄
• SMILES: Cl.CN(C)CCOc1ccc2[nH]c(cc2c1)C(=O)NCC#Cc1ccc(cc1)C(=O)NO
• Target: Apoptosis,HDAC
• Solubility: DMSO:50 mg/mL (109.43 mM)

Bioactivity

• Target IC50:
  HDAC10:20 nM|HDAC8:7 nM|HDAC6:15 nM|HDAC3/SMRT:11 nM|HDAC2:14 nM|HDAC1:4 nM
• In Vivo:
  CRA-026440 hydrochloride (100 mg/kg; intravenous injection; daily; three consecutive days) resulted in a significant decrease in tumor growth in mice carrying HCT116 or U937 human tumor xenografts.
• In Vitro:
  CRA-026440 hydrochloride exhibits anti-proliferation effect on HUVEC endothelial cells with GI50 of 1.41 μM. CRA-026440 hydrochloride leads to the accumulation of acetylated histone and acetylated tubulin, thus inhibiting the growth of tumor cells and inducing cell apoptosis. CRA-026440 hydrochloride inhibits angiogenesis in vitro in a dose-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

847460-34-8, 847460-34-8 Free base, CRA 026440 Hydrochloride, CRA026440 Hydrochloride, CRA-026440 Hydrochloride, CRA-026440 hydrochloride(847460-34-8 Free base), HDAC

Compound Identifiers

PubChem CID

11619469