CQ211

SKU: orb1686397

Description

CQ211 is a potent and selective RIOK2 inhibitor exhibiting a 6.1 nM binding affinity. It demonstrates robust anti-proliferative effects in vitro across multiple cancer cell lines and has been utilized in research exploring oncogenic kinase signaling and potential therapeutic applications.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 2648986-65-4
• MW: 521.49
• Purity: >99.99% (May vary between batches)
• Formula: C₂₆H₂₂F₃N₇O₂
• SMILES: O=C1C2=C(C=3C(N1)=CC=C(C3)C=4C=CC(OC)=NC4)N(N=N2)C5=CC(C(F)(F)F)=C(C=C5)N6CCNCC6
• Target: Serine/threonin kinase,Others
• Solubility: DMSO:6.25 mg/mL (11.98 mM)

Bioactivity

• Target IC50:
  RIOK2:6.1 nM(Kd)
• In Vivo:
  CQ211 (25 mg/kg; rat) inhibits the tumor progression with tumor growth inhibition (TGI) of 30.9%.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rio2 kinase (RIOK2)

Compound Identifiers

PubChem CID

163408925