(±)-CPSI-1306

SKU: orb1307587

Description

(±)-CPSI-1306 is a macrophage migration inhibitory factor (MIF) antagonist. This small molecule is used in research applications investigating type 2 diabetes (NIDDM) and has shown potential in preclinical studies for mitigating skin damage caused by UVB radiation exposure.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1309793-47-2
• MW: 310.3
• Purity: 97.98% (May vary between batches)
• Formula: C₁₅H₁₆F₂N₂O₃
• SMILES: Fc1ccc(C2=NOC(CC(=O)N3CCOCC3)C2)c(F)c1
• Target: MIF,Others
• Solubility: DMSO:45 mg/mL (145.02 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (3.22 mM)

Bioactivity

• In Vivo:
  In mice, (±)-CPSI-1306 decreases their blood glucose levels and can be effective in treating non-insulin-dependent diabetes mellitus (NIDDM) as characterized by high serum levels of glucose and inflammatory cytokine. (±)-CPSI-1306-induced keratinocyte apoptosis is appreciated 30 minutes after a single UVB exposure. (±)-CPSI-1306-treated mice show a significant increase in expression of cleaved caspase-3 at 6, 24, and 48 hours following UVB exposure. (±)-CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MIF, 2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one, CPSI1306, cpsi-1306, CPSI-1306, CPSI 1306

Compound Identifiers

PubChem CID

59723793