CPS-11

SKU: orb1703581

Description

CPS-11 (N-(Hydroxymethyl)thalidomide) is a potent thalidomide analog with significant antitumor activity, demonstrating particular efficacy against multiple myeloma (MM) cell lines in vitro. Its expanded activity profile makes it a valuable research tool for investigating hematological cancers and novel immunomodulatory agents.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 145945-21-7
• MW: 288.26
• Purity: 99.98% (May vary between batches)
• Formula: C₁₄H₁₂N₂O₅
• SMILES: O=C1N(C(=O)C=2C1=CC=CC2)C3C(=O)N(CO)C(=O)CC3
• Target: NF-κB,Reactive Oxygen Species,Dehydrogenase,ROS
• Solubility: DMSO:45 mg/mL (156.11 mM)

Bioactivity

• In Vitro:
  Confirming its ability to target tumor cells in the bone marrow microenvironment, CPS-11 abrogates the ability of bone marrow stromal cells (BMSCs) to induce proliferation of MM cells. Showing virtually no effect on the activation of p38 and only slight, transient activation of ATF2 and HSP27 (0-200 μM, 0 or 4 h), CPS-11 demonstrates its pharmacological behavior. At doses as high as 100 μM, CPS-11 (0-100 μM, 24 or 48 h) exhibits no toxicity to H157 cells, WT MEFs, or the p38α-/- MEFs. Furthermore, CPS-11 (50 μM, 24 or 48 h) does not induce apoptosis in H157 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CPS11, CPS-11, CPS 11, hDHFR(dihydrofolate reductase), N-(Hydroxymethyl)thalidomide, NFkB, NF-kB, NFκB, NF-κB, Nuclear factor of activated Tcells (NFAT), ReactiveOxygenSpecies, Reactive Oxygen Species

Compound Identifiers

PubChem CID

9900574