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CPI203

SKU: orb1226264

Description

CPI 203 (TEN 010, JQ-2, RG-6146) is a primary amide analog of (+)-JQ1and a BET bromodomain inhibitor that shows cytotoxicity against MCL cell lines with GI50 of 0.1-0.3 uM; synergizes the antitumor activity of lenalidomide in bortezomib-resistant mantle cell lymphoma; also enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors, overcomes resistance to ABT-199 (Venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma.

Images & Validation

Key Properties

CAS Number1446144-04-2
MW399.897
Purity>98% (HPLC)
FormulaC19H18ClN5OS
SMILESO=C(N)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1
TargetBromodomain
SolubilityDMSO: 72 mg/mL (180 mM); Ethanol: 5 mg/mL (12.5 mM); Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TEN 010 | JQ-2 | RG-6146

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CPI203 (orb1226264)

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Available Sizes

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100 mg
200 mg
500 mg
2 mg
$ 110.00
5 mg
$ 170.00
10 mg
$ 250.00
25 mg
$ 500.00
50 mg
$ 740.00