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CPI-169

SKU: orb1223296

Description

CPI-169 is a potent inhibitor of enhancer of zeste homolog 2 (EZH2) with an IC50 value of <1nM for polycomb repressive complex 2 (PRC2). CPI-169 was shown to inhibit tumor growth in a NHL xenograft model, reducing global H3K27me3.1 It has also been shown to synergize with the B-cell lymphoma inhibitor, ABT-199, to suppress the growth of NHL cell lines.

Images & Validation

Key Properties

CAS Number1450655-76-1
MW528.66
Purity>98% (HPLC)
FormulaC27H36N4O5S
SMILESCCS(=O)(=O)N1CCC(CC1)C(C)n1c2ccccc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C
TargetALK
SolubilityDMSO : ≥ 59 mg/mL. 111.60 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CPI-169 | CPI 169 | CPI169

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    1450655-76-1

    528.66

    C27H36N4O5S

    1 ml x 10 mM (in DMSO), 1 mg, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
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Protocol Information

CPI-169 (orb1223296)

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Available Sizes

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200 mg
500 mg
2 mg
$ 130.00
5 mg
$ 200.00
10 mg
$ 260.00
25 mg
$ 540.00
50 mg
$ 780.00
100 mg
$ 1,100.00