CPI-1189

SKU: orb1223219

Description

REN-1189 is a TNF-a release inhibitor potentially for the treatment of sciatica and postherpetic neuralgia.

Key Properties

• CAS Number: 183619-38-7
• MW: 234.3
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₈N₂O₂
• SMILES: CC(=O)Nc1ccc(cc1)C(=O)NC(C)(C)C
• Target: TNF-α
• Solubility: In Vitro: DMSO : 100 mg/mL (426.82 mM)

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: SH-SY5Y oncentration: 10, 30, 100, 300 nM Incubation time: 1 h. Result: Alleviated OGDR-induced cytotoxicity in a concentration-dependent manner. Apoptosis Analysis Cell line: SH-SY5Y. Concentration: 100 nM. Incubation time: 1 h. Result: Inhibited OGDR-induced caspase-3/-9 activation and ssDNA accumulation. Attenuated OGDR-induced apoptosis activation.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CPI-1189 | REN-1189 | REN-1654 | REN1189

Quick Database Links

Gene Symbol

TNF-α