CPDA

SKU: orb1309814

Description

CPDA is a potent and selective small molecule inhibitor of the SHIP2 phosphatase. It is a valuable research tool for studying SHIP2's role in insulin signaling, cancer cell proliferation, and metabolic disorders in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1415834-63-7
• MW: 388.8
• Purity: 98.34% (May vary between batches)
• Formula: C₂₀H₁₅ClF₂N₂O₂
• SMILES: Fc1cccc(F)c1CC(=O)Nc1cc(OCc2ccc(Cl)cc2)ccn1
• Target: Phosphatase
• Solubility: DMSO:50 mg/mL (128.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.14 mM)

Bioactivity

• In Vivo:
  CPDA significantly enhances abnormal glucose metabolism in diabetic animals, as evidenced by its effectiveness in improving glucose metabolism in db/db mice.
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• In Vitro:
  CPDA enhances insulin signaling. CPDA was found to enhance in vitro insulin signaling through the Akt pathway more efficiently than the previously reported SHIP2 inhibitor AS1949490, and ameliorated abnormal glucose metabolism in diabetic (db/db) mice.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Phosphatase, SHIP2, Inhibitor, inhibit, CPDA

Compound Identifiers

PubChem CID

71089297