CPAG-1

SKU: orb3174033

Description

CPAG-1 is a small molecule activator of the progesterone receptor membrane component 2 (PGRMC2). It facilitates the delivery of mitochondrially-produced heme to the nucleus via PGRMC2 and activates thermogenesis-related genes like Ucp1 and Pgc-1α in brown adipose tissue (BAT), while reducing lipid accumulation in BAT. Additionally, CPAG-1 lowers fasting blood glucose and insulin levels, improving glucose tolerance and insulin sensitivity. It is applicable for research in type 2 diabetes.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2094991-62-3
• MW: 326.44
• Formula: C₂₀H₂₆N₂O₂
• SMILES: N(C([C@@H](NC(CCC)=O)CC(C)C)=O)C1=CC2=C(C=C1)C=CC=C2
• Target: Progesterone Receptor,PGC-1α

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Progesterone Receptor,PGC-1α