CP21R7

SKU: orb1226674

Description

A high-affinity, selective GSK3β inhibitor that activates canonical Wnt signaling; promotes rapid and efficient differentiation of human pluripotent stem cells (hPSCs) into vascular endothelial and smooth muscle cells.(In Vitro):CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm.

Key Properties

• CAS Number: 125314-13-8
• MW: 317.3413
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₅N₃O₂
• SMILES: O=C(C(C1=CC=CC(N)=C1)=C2C3=CN(C)C4=C3C=CC=C4)NC2=O
• Target: GSK-3
• Solubility: DMSO: ≥ 32 mg/mL

Bioactivity

• In Vitro:
  CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CP21

Quick Database Links

Gene Symbol

GSK-3