CP-99994

SKU: orb3173281

Description

CP-99994 is a neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. It prevents colorectal sensitization under conditions of visceral hypersensitivity and reduces acetic acid-induced colorectal sensitization in a bladder-colon cross-sensitization model. CP-99994 also attenuates neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity.

Research Area

Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 136982-36-0
• MW: 296.41
• Formula: C₁₉H₂₄N₂O
• SMILES: N(CC1=C(OC)C=CC=C1)[C@@H]2[C@@H](NCCC2)C3=CC=CC=C3
• Target: Neurokinin receptor,p38 MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Neurokinin receptor,p38 MAPK