CP-868388 free base

SKU: orb1697667

Description

CP-868388 free base is a potent, selective, and orally bioavailable PPARα agonist. It demonstrates hypolipidemic and anti-inflammatory effects in research models, supporting its investigation for dyslipidemia and related metabolic disorders in both in vitro and in vivo studies.

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 702681-67-2
• MW: 439.54
• Purity: 99.84%
• Formula: C₂₆H₃₃NO₅
• SMILES: CC(C)c1ccc(COC(=O)N2CCC[C@H](C2)c2cccc(OC(C)(C)C(O)=O)c2)cc1
• Target: PPAR
• Solubility: DMSO:100 mg/mL (227.51 mM)

Bioactivity

• Target IC50:
  PPARγ (human):3.47 μM (Ki)|HepG2 cells:18 nM (EC50)|SRC-1:4.7 nM (EC50)|PPARα (human):10.8 nM (Ki)
• In Vivo:
  In male B6/CBF1J mice, treatment with CP-868388 (oral gavage; once daily; for 2 days) at doses ranging from 0-3 mg/kg results in a robust and highly significant decrease in circulating plasma triglycerides. The dose-dependent effect is observed, with the highest efficacy achieved at the 3.0 mg/kg dose, leading to a reduction of approximately 50% in triglyceride levels.
• In Vitro:
  The compound CP-868388, at concentrations ranging from 0-1 mM, exhibits strong and dose-dependent recruitment of SRC-1, with an EC50 of 4.7 nM, as well as the PGC-1α peptide. Additionally, CP-868388 demonstrates potent and selective transcriptional activation of PPARα, showing an EC50 of 18 nM in HepG2 cells.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(-)-CP-868388, CP868388, CP-868388, CP868388 free base, CP-868388 free base, CP 868388, CP 868388 free base, PPARα, UNII-999KY5ZIGB

Compound Identifiers

PubChem CID

10433320