CP-809101 hydrochloride

SKU: orb1309815

Description

CP-809101 hydrochloride is a highly potent and selective agonist for the human 5-HT2C receptor, demonstrating significant selectivity over the 5-HT2B and 5-HT2A subtypes. This compound is a valuable pharmacological tool for investigating serotonin receptor function in both in vitro and in vivo models related to neuropsychiatric and metabolic disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1215721-40-6
• MW: 341.24
• Purity: 99.50% (May vary between batches)
• Formula: C₁₅H₁₈Cl₂N₄O
• SMILES: Cl.Clc1cccc(COc2cncc(n2)N2CCNCC2)c1
• Target: 5-HT Receptor
• Solubility: H2O:20 mg/mL (58.61 mM)

Bioactivity

• Target IC50:
  5-HT2B:7.19(pEC50 for human)|5-HT2C:9.96(pEC50 for human)|5-HT2A:6.81(pEC50 for human)
• In Vivo:
  Similar to currently available antipsychotic drugs, CP-809101 dose-dependently inhibited conditioned avoidance responding (CAR, ED50 = 4.8 mg/kg, sc). CP-809101 antagonized both PCP- and d-amphetamine-induced hyperactivity with ED50 values of 2.4 and 2.9 mg/kg (sc), respectively, and also reversed an apomorphine induced-deficit in prepulse inhibition. At doses up to 56 mg/kg, CP-809101 did not produce catalepsy. CP-809101 was inactive in two animal models of antidepressant-like activity, the forced swim test, and learned helplessness.
• In Vitro:
  CP-809101 is a potent, functionally selective 5-HT2C agonist that displays approximately 100% efficacy in vitro.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CP809101, CP-809101, CP809101 Hydrochloride, CP809101 hydrochloride, CP-809101 Hydrochloride, CP 809101, CP 809101 hydrochloride, CP 809101 Hydrochloride, conditioned avoidance responding, 5HTReceptor, 5-hydroxytryptamine Receptor, 5HT Receptor, 5-HT Receptor, 5-HT2A, 5-HT2B, 5-HT2C, antipsychotic, hyperactivity, nicotine, nicotine dependence, Inhibitor, inhibit, Serotonin Receptor

Compound Identifiers

PubChem CID

56972220