CP-547632

SKU: orb1709995

Description

CP-547632 is a potent, orally bioavailable dual inhibitor of VEGFR-2 and FGF receptor kinases, demonstrating high selectivity and antitumor efficacy. It has been utilized in cancer research to study angiogenesis and tumor growth inhibition in both cellular assays and animal xenograft models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 252003-65-9
• MW: 532.4
• Purity: 99.39% (May vary between batches)
• Formula: C₂₀H₂₄BrF₂N₅O₃S
• SMILES: NC(=O)c1c(NC(=O)NCCCCN2CCCC2)snc1OCc1c(F)cc(Br)cc1F
• Target: BTK,VEGFR,FGFR,PDGFR
• Solubility: DMSO:90 mg/mL (169.05 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.51 mM)

Bioactivity

• Target IC50:
  VEGFR2:11 nM|FGFR:9 nM
• In Vivo:
  CP-547632 (oral ; 50 mg/kg) yieldes plasma concentrations above 500 ng/ml for 12 hours. CP-547632 (p.o. ; 6.25-100 mg/kg/day ; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.
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• In Vitro:
  CP-547632 (1-1000 nM ; 1 h) suppresses VEGF-induced VEGFR-2 phosphorylation in a concentration-dependent manner (IC50: 6 nM).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BTK, bFGFR, CP547632, CP-547632, CP 547632, FGFR, PDGFRβ, VEGFR-2, VEGFR2

Compound Identifiers

PubChem CID

9811611