CP 424174

SKU: orb1298602

Description

CP 424174 is a potent and orally bioavailable small molecule inhibitor that blocks the post-translational processing of IL-1β (IC₅₀ = 210 nM), preventing the generation of mature cytokine. This action indirectly inhibits the NLRP3 inflammasome, making it a valuable tool for researching inflammatory pathways in both cellular assays and animal models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 210825-31-3
• MW: 452.99
• Purity: >99.99% (May vary between batches)
• Formula: C₂₂H₂₉ClN₂O₄S
• SMILES: CC(C)c1cc(Cl)cc(C(C)C)c1NC(=O)NS(=O)(=O)c1cccc(c1)C(C)(C)O
• Target: IL Receptor,NOD-like Receptor (NLR)
• Solubility: DMSO:27.5 mg/mL (60.71 mM)

Bioactivity

• Target IC50:
  IL-1β:210 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CP424174, CP-424174, CP 424174, inhibit, Inflammasome, IL-1β, IL Receptor, ILReceptor, NLRP3, NOD-like Receptor (NLR), Inhibitor

Compound Identifiers

PubChem CID

9911728