CP-24879 hydrochloride

SKU: orb1305137

Description

CP-24879 hydrochloride is a dual Δ5-desaturase and Δ6-desaturase inhibitor. It effectively reduces hepatic lipid accumulation and inflammation, as demonstrated in both in vitro hepatocyte studies and in vivo models, including fat-1 transgenic mice. This makes it a valuable research tool for investigating steatosis and related metabolic disorders.

Research Area

Cell Biology

Key Properties

• CAS Number: 10141-51-2
• MW: 215.72
• Purity: 98.78% (May vary between batches)
• Formula: C₁₁H₁₈ClNO
• SMILES: Cl.CC(C)CCOc1ccc(N)cc1
• Target: Others,Ferroptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.27 mM);DMSO:55 mg/mL (254.96 mM)

Bioactivity

• Target IC50:
  Δ6D:0.56 μM(ABMC-7 cells)|Δ6D:0.56 μM(Liver microsomes)|Δ5D:0.67 μM (ABMC-7 cells)|Δ5D:3.4 μM (Liver microsomes)
• In Vivo:
  In Chow-fed and EFAD Balb/C mice, CP-24879 hydrochloride (3 mg/kg, i.p.) inhibited approximately 80% combined Δ6 + Δ5 desaturase activities, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice, and increased OA and LA, with a higher ratio of LA/AA in the livers of mice injected with CP-24879 versus saline (4.70 vs 2.00, Chow-fed mice; 2.46 vs 1.40, EFAD mice; respectively).
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• In Vitro:
  CP-24879 hydrochloride (0-10 μM, 16 h) blocked LPS-induced expression of inflammatory cytokines in a concentration-dependent manner and showed the inhibitory responses on oleic acid-induced triglyceride accumulation in hepatocytes. CP-24879 hydrochloride (0-10 μM, 4 days) inhibited Δ6 + Δ5 desaturase activities in a concentration-dependent manner, with a concentration-dependent depletion of AA and a decrease in Leukotriene C4 (LTC4) production, and did not inhibit either 5-lipoxygenase or LTC4 synthase activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ferroptosis, Fatty acid desaturase inhibitor, Fatty acid desaturase Δ5D, Fatty acid desaturase Δ6D, Inhibitor, inhibit, Non-alcoholic steatohepatitis, CP24879, CP-24879, CP-24879 HCl, CP24879 Hydrochloride, CP24879 hydrochloride, CP-24879 Hydrochloride, CP 24879, CP 24879 Hydrochloride, CP 24879 hydrochloride, Anti-inflammatory active

Compound Identifiers

PubChem CID

16078965