CP 154526 hydrochloride

SKU: orb1704602

Description

CP 154526 hydrochloride is a potent and selective CRF1 receptor antagonist (Ki = 2.7 nM) with high blood-brain barrier permeability. It demonstrates anxiolytic and antidepressant effects in vivo and is a valuable research tool for studying stress-related disorders in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 257639-98-8
• MW: 400.99
• Purity: 99.94% (May vary between batches)
• Formula: C₂₃H₃₃ClN₄
• SMILES: Cl.N=1C(=NC(=C2C1N(C=C2C)C=3C(=CC(=CC3C)C)C)N(CC)CCCC)C
• Target: CRFR
• Solubility: DMSO:80 mg/mL (199.51 mM)

Bioactivity

• Target IC50:
  CRF1:2.7 nM (Ki)
• In Vivo:
  CP 154526 hydrochloride (1-10 mg/kg, single intraperitoneal injection) demonstrated anxiolytic activity characteristics in the elevated plus maze behavioral test in rats .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CP154526, CP-154526, CP154526 hydrochloride, CP-154526 hydrochloride, CP 154526

Compound Identifiers

PubChem CID

11475094