COX-2-IN-55

SKU: orb3135635

Description

COX-2-IN-55 (compound 1) is an orally active Celecoxib analogue with broad-spectrum anticancer properties and relatively weak COX-2 inhibition. It specifically inhibits SERCA2, leading to increased caspase-3 cleavage and DR5 levels, which activates GRP78 and suppresses the progression of triple-negative breast cancer (TNBC). Additionally, COX-2-IN-55 downregulates the angiogenesis markers VEGF-α and IL-8, thereby inhibiting microvessel formation.

Key Properties

• CAS Number: 2649115-80-8
• MW: 486.51
• Formula: C₂₄H₂₁F₃N₄O₂S
• SMILES: O=S(=O)(NC=1C=CC=C(N)C1)C2=CC=C(C=C2)N3N=C(C=C3C=4C=C(C=CC4C)C)C(F)(F)F
• Target: Calcium Channel,Caspase,VEGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Calcium Channel,Caspase,VEGFR