Coumestrol

SKU: orb1296071

Description

Coumestrol, a soy-derived phytoestrogen, suppresses ES2 ovarian cancer cell proliferation in vitro (IC50: 50 µM). Research indicates its potential relevance in studying neurological disorders, cancers, and autoimmune diseases, with investigations extending to animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 479-13-0
• MW: 268.22
• Purity: 99.23% (May vary between batches)
• Formula: C₁₅H₈O₅
• SMILES: Oc1ccc2c(c1)oc1c2c(=O)oc2cc(O)ccc12
• Target: Estrogen Receptor/ERR
• Solubility: Methanol:20 mg/mL (74.57 mM);DMSO:25 mg/mL (93.21 mM);10% DMSO+90% Saline:2 mg/mL (7.46 mM)

Bioactivity

• In Vitro:
  Coumestrol inhibits proliferation and induces apoptosis in MCF-7 cells, which is prevented by copper chelator neocuproine and ROS scavengers. Coumestrol treatment induces ROS generation coupled to DNA fragmentation, up-regulation of p53/p21, cell cycle arrest at G1/S phase, mitochondrial membrane depolarization and caspases 9/3 activation . Coumestrol inhibits viability and invasion and induces apoptosis of ES2 (clear cell-/serous carcinoma origin) cells. In addition, immunoreactive PCNA and ERBB2, markers of the proliferation of ovarian carcinoma, are attenuated in their expression in coumestrol-induced death of ES2 cells. Phosphorylation of AKT, p70S6K, ERK1/2, JNK1/2, and p90RSK is inactivated by coumestrol treatment in a dose- and time-dependent manner .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Coumestrol, ERR, Estrogen Receptor, EstrogenReceptor, Estrogen Receptor/ERR, Inhibitor, inhibit

Compound Identifiers

PubChem CID

5281707