Coumarin

SKU: orb1310304

Description

Coumarin is a naturally occurring compound found in plants like tonka beans and woodruff. It serves as a key precursor for anticoagulant drugs like warfarin and is widely used in biochemical research for studying coagulation mechanisms in both in vitro and in vivo models.

Research Area

Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 91-64-5
• MW: 146.14
• Purity: 99.96% (May vary between batches)
• Formula: C₉H₆O₂
• SMILES: O=C1OC2=CC=CC=C2C=C1
• Target: Antifungal,Influenza Virus,Antibacterial,Factor Xa
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (17.11 mM);DMSO:250 mg/mL (1710.69 mM);Ethanol:28 mg/mL (191.6 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  Coumarin is a fragrant organic chemical compound in the benzopyrone chemical class, which is a colorless crystalline substance in its standard state. Coumarin is a naturally occurring constituent of many plants and essential oils, including tonka beans, sweet clover, woodruff, oil of cassia, and lavender. Coumarin is a member of a class of compounds called benzopyrones. Coumarin compounds have been used to treat such diverse ailments as cancer, bums, brucellosis, and rheumatic disease, and they have been used as antispasmodics. Although coumarin itself has no anticoagulant properties, it is transformed into the natural anticoagulant dicoumarol by a number of species of fungi. This occurs as the result of the production of 4-hydroxycoumarin, then further into the actual anticoagulant dicoumarol, a fermentation product and mycotoxin. This substance is responsible for the bleeding disease known historically as 'sweet clover disease' in cattle eating moldy sweet clover silage.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Coumarin, Influenza Virus, InfluenzaVirus, inhibit, Inhibitor, Factor Xa, FactorXa, vitamin K

Compound Identifiers

PubChem CID

323