Cot-IN-4

SKU: orb3174073

Description

Cot-IN-4 (compound 32) is a potent inhibitor of cancer Osaka thyroid (COT) kinase, with an IC50 value of 6 nM. It effectively inhibits the phosphorylation of ERK (IC50: 60 nM) and suppresses the release of TNFα (IC50: 60 nM). Additionally, Cot-IN-4 reduces the production of the pro-inflammatory cytokine IL-1β in macrophages stimulated by uric acid (IC50: 0.2 μM). This compound is applicable for research in inflammatory diseases.

Key Properties

• CAS Number: 1984784-10-2
• MW: 516.61
• Formula: C₃₀H₂₈N₈O
• SMILES: N1=CC=C(C=C1)C=2N=CC=3N=CC=4N=CN(C=5C=CC6=NC(=CC=C6C5)NC(C)CN7CCOCC7)C4C3C2
• Target: Interleukin,MAPK,TNF,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,MAPK,TNF,ERK