Cosalane

SKU: orb1703582

Description

Cosalane (NSC 658586) is a small molecule inhibitor of HIV replication and CCR7 signaling. It functions by blocking the interaction between the chemokine receptor CCR7 and its ligands CCL19/CCL21. This compound has demonstrated antiviral activity and is utilized in immunological and virological research, including studies on lymphocyte migration and HIV entry mechanisms in vitro.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 154212-56-3
• MW: 767.86
• Purity: >99.99% (May vary between batches)
• Formula: C₄₅H₆₀Cl₂O₆
• SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)[H])[H])(CC[C@]1(C[C@@H](CCC=C(C5=CC(C(O)=O)=C(O)C(Cl)=C5)C6=CC(C(O)=O)=C(O)C(Cl)=C6)CC2)[H])[H])[H]
• Target: CXCR,HIV Protease,HSV,CCR
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (4.3 mM);DMSO:100 mg/mL (130.23 mM)

Bioactivity

• Target IC50:
  HSA:1.24 ± 0.24 nM (Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC658586, NSC-658586, NSC 640067, NSC 658586, HIV, HIV Protease, HIVProtease, Cosalane

Compound Identifiers

PubChem CID

455040