Corylin

SKU: orb1221612

Description

Corylin is a major bioactive compound isolated from Psoralea corylifolia L; it has the activity of antibiotic or anticancer.

Key Properties

• CAS Number: 53947-92-5
• MW: 320.3
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₆O₄
• SMILES: CC1(C=CC2=C(O1)C=CC(=C2)C3=COC4=C(C3=O)C=CC(=C4)O)C
• Target: MMP
• Solubility: DMSO : ≥ 100 mg/mL 312.17 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vivo:
  Animal model: HFD-and DIO-treated mice. Dosage: 50-100 mg/kg. Administration: Oral gavage (p.o.), daily, 9 weeks. Result: Reduced the weight of subcutaneous, visceral WAT, and body. Decreased the size of WAT adipocyte. Increased insulin sensitivity, mitochondrial biogenesis, and β-oxidation. Reduced serum levels of insulin and leptin and improved HOMA-IR.
• In Vitro:
  Western blot analysis. Cell line: HepG2 and Huh7 cells. Concentration: 3-30 μM. Incubation time: 24-48 h. Result: Reduced the expression of EMT-promoting proteins such as N-cadherin, vimentin, slug, and twist.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MMP