Corydaline

SKU: orb1222126

Description

Corydaline is isolated from Corydalis yanhusuo. It exhibits many activities, including increaseing gastric emptying and small intestine transit seed, decreasing chemically induced pain, and potentially suppressing mast cell dependent smooth muscle contracting of the aorta.

Key Properties

• CAS Number: 518-69-4
• MW: 369.46
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₇NO₄
• SMILES: CC1C2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC
• Target: CYP2C|CYP2C9
• Solubility: DMSO : 33.33 mg/mL 90.22 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vivo:
  Animal model: Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid. Dosage: 10 mg/kg. Administration: Subcutaneous administration; once. Result: Showed antinociceptive effects in mice.
• In Vitro:
  Western blot analysis. Cell line: Vero cellsinfected with EV71. Concentration: 12.5 μM, 25 μM, 50 μM Incubation time: 24 hours. Result: Reduced the phosphorylation of P38 MAPK and JNK MAPK and the expression of COX-2.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Corydalin | BRN 0096972 | NSC-406036 | NSC406036

Quick Database Links

Gene Symbol

CYP2C|CYP2C9