Corosolic acid

SKU: orb1222249

Description

Corosolic acid is a pentacyclic triterpene acid found in Lagerstroemia speciosa. It is similar in structure to ursolic acid, differing only in the fact that it has a 2-alpha-hydroxy attachment. Corosolic acid has numerous biological properties, including antidiabetic, anti-inflammatory, antiproliferative, and protein kinase C inhibition activity. However, there is a lack of clinical evidence to support these uses.

Key Properties

• CAS Number: 4547-24-4
• MW: 472.7
• Purity: >98% (HPLC)
• Formula: C₃₀H₄₈O₄
• SMILES: C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]3[C@@]4(C[C@H]([C@@H](C3(C)C)O)O)C)C)[C@@H]2[C@H]1C)C)C(=O)O
• Target: STAT
• Solubility: DMSO : ≥ 50 mg/mL 105.78 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vivo:
  Animal model: CT-26 allograft colon carcinoma mice model. Dosage: 5, 25 mg/kg/day. Administration: Peritumor injection, 12 days. Result: Reduced the tumor weight to 76.2% and 53.8% of the control group. Reduced blood and lymphatic vessel densities. Animal model: high-fat fed mice. Dosage: 10 mg/kg/day. Administration: Supplemented in diet, 8 weeks. Result: Inhibited hyperlipidemia, Improved insulin sensitivity and glucose intolerance. Inhibited inflammation in adipose tissues. Inhibited macrophage infiltrations into adipose tissue.
• In Vitro:
  Apoptosis Analysis Cell line: CT-26 cells. Concentration: 25 μM. Incubation time: 12 and 24 h. Result: Increased cleaved caspase-3 level. Increased cells in the sub-G1 population. Increased fluorescin-dUTP labeling DNA strand breaks. Western blot analysis. Cell line: HCT116 and SW480 cells. Concentration: 20 μM. Incubation time: 0-24 h. Result: Decreased the formation of NRG1-induced HER2/HER3 heterodimer. Inhibited the PI3K/Akt/PDE3B but not the ERK1/2 signaling pathway.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Glucosol

Quick Database Links

Gene Symbol

STAT