Coralyne chloride

SKU: orb1304539

Description

Coralyne chloride

Research Area

Molecular Biology

Key Properties

• CAS Number: 38989-38-7
• MW: 399.87
• Purity: 98.88% (May vary between batches)
• Formula: C₂₂H₂₂ClNO₄
• SMILES: [Cl-].COc1cc2cc[n+]3c(C)c4cc(OC)c(OC)cc4cc3c2cc1OC
• Target: Topoisomerase
• Solubility: DMSO:1.5 mg/mL (3.75 mM);H2O:3 mg/mL (7.5 mM)

Bioactivity

• In Vitro:
  There is synergism between Coralyne and Paclitaxel on proliferation and migration of breast cancer cell lines. This study also showed that combinational drug treatment decreased the expression of ki-67 and there was an increase in pro apoptotic factor Bax with decreased in expression of anti-apoptotic factor Bcl-2 in breast cancer cell lines with negligible effect on normal breast cell line.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, neurodrug, Antileukemic, cancer, Coralyne, Coralyne Chloride, Coralyne chloride, Topoisomerase, protoberberine, topoisomerase I

Compound Identifiers

PubChem CID

23306