Copper histidine

SKU: orb1745202

Description

This research compound, copper histidine, inhibits the Ctr1 transporter to block oxaliplatin uptake in vitro, yet does not affect platinum accumulation or neurotoxicity in DRG tissues in vivo. It is a key agent for studying copper metabolism, Menkes disease, and mechanisms of platinum-based chemotherapeutic resistance and neurotoxicity.

Key Properties

• CAS Number: 77280-83-2
• MW: 217.69
• Purity: 96.81%
• Formula: C₆H₈CuN₃O₂
• SMILES: O=C1[O-][Cu+2]2[N]3(C(C[C@@]1([NH2]2)[H])=CN=C3)[H]
• Target: Others
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  Copper histidine (10 lmol/L) inhibited cellular uptake of oxaliplatin mediated by Ctr1 in HEK293 cells overexpressing rat Ctr1.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171041087