coniferyl ferulate

SKU: orb1303445

Description

Coniferyl ferulate, isolated from Radix Angelicae sinensis, is a potent inhibitor of glutathione S-transferase (GST) with an IC50 of 0.3 μM against the human placental isoform. This small molecule also demonstrates the ability to reverse multidrug resistance by downregulating P-glycoprotein, making it a valuable tool for in vitro cancer research and MDR mechanism studies.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 63644-62-2
• MW: 356.37
• Purity: 97.09% (May vary between batches)
• Formula: C₂₀H₂₀O₆
• SMILES: COc1cc(\C=C\COC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
• Target: iGluR,p38 MAPK,Antibacterial,GST,P-gp,ROS,Apoptosis,CaMK
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (5.61 mM);DMSO:20 mg/mL (56.12 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ABCB1, coniferyl ferulate, CD243, Cluster of differentiation 243, Inhibitor, inhibit, Multidrug resistance protein 1, Gutathione S-transferase, Glutathione transferases, GSTs, GST, MDR1, P-glycoprotein, Pgp, P-gp, P-gp (P-glycoprotein)

Compound Identifiers

PubChem CID

6441913